Innovations that shaped a decade of healthcare

On Eve of 2015 Medical Innovation Summit, Cleveland Clinic Looks Back at the Decade's 10 Most Powerful Medical Innovations

CLEVELAND, Oct. 22, 2015 /PRNewswire/ -- Each year, at the close of its annual Medical Innovations Summit, Cleveland Clinic predicts the Top 10 Medical Innovations for the coming year.

That tradition turns 10 years old this year. In recognition of a decade of highlighting medical innovation, an advisory panel of Cleveland Clinic doctors helped to compile a "throwback" Top 10, a listing of the top medical innovations of the past 10 years.

Their review of past Top 10 lists reveals that many of the innovations were indeed transformative.

The 2015 Medical Innovation Summit begins Sunday at the Cleveland Convention Center. The Top 10 Medical Innovations for 2016 will be unveiled at 11 a.m. Wednesday, October 28, the summit's final day. In the spirit of innovation, here are the Top 10 medical innovations of the past 10 years:

1. Harnessing Big Data to Improve Healthcare (2011)

As predicted in 2011, Big Data has become big business as American hospitals adopt electronic medical records. Researchers are using computers to analyze those records to spy disease patterns, discover cures and identify best treatment practices.

Companies like IBM are diving deep into the game, expanding their offering of healthcare analytics. Meanwhile, new wearable devices collect even more health data to be crunched and acted upon.

According to a recent study by IQ4I Research and Consultancy, spending on data analytics in healthcare will grow by more than 40 percent over the next four years to become a $20 billion global market.

2. New Era in Hepatitis C Treatment (2014)

There are an estimated 170 million people worldwide infected with Hepatitis C, an often undetected virus that causes slow, progressive damage to the liver. For decades, interferon-based treatments produced low success rates. But new, interferon-free treatments have proven much more effective, giving doctors hope that the disease could be eradicated.

3. Bariatric Surgery for Control of Diabetes (2013)

This innovation offers hope for fighting a chronic and debilitating disease that afflicts millions. Studies of the long-term effectiveness of bariatric surgery to control diabetes have found that after a five-year follow-up, over half of Type II diabetes patients had either complete or partial remission.

4. Percutaneous Aortic Heart Valves (2008)

This alternative to open-heart surgery is now the standard treatment for many high-risk cardiac patients.

Using a catheter, a doctor inserts a wire mesh valve through an artery and into the heart, where it pops open and replaces the damaged valve. There are four aortic valve devices FDA approved for percutaneous repair or replacement, and the technology is expanding to percutaneous mitral valve repair, with some devices seeking FDA approval this year.

5. New Strategies for Creating Vaccines for Fighting Flu (2009)

A new vaccine strategy not only defended against a deadly flu virus, it helped healthcare workers confront pandemics. Researchers used a mock version of the bird flu virus, called a virus-like particle (VLP), to ward off avian flu. Because they do not require a live virus, VLP-based vaccines are easier and faster to produce. They allow public health authorities to respond more swiftly to alarming infections. In 2014, scientists began using VLP strategies to develop an Ebola vaccine, which is expected to be ready in 2016.

6. Checkpoint Inhibitors (2015)

In 2014, Cleveland Clinic doctors spied the potential of immune checkpoint inhibitors, new tools in the fight against cancer. Since then, three immune checkpoint inhibitors have been approved for use in patients with melanoma, creating sales of over $1.5 billion in 2014, and one has been granted priority review for use in lung cancer patients. Additionally, there are more than 80 companies researching 148 immune checkpoint inhibitors associated with various cancers, with 10 in the last phase of clinical trials.

7. PCSK9 Inhibitors for Cholesterol Reduction (2015)

This new class of cholesterol-reducing drugs recently received FDA approval. Doctors are ready to prescribe it to 17 percent of their patients with dangerously high LDL levels, potentially creating a $3 billion market.

8. Dual Energy Source Computed Tomography (CT) Imaging (2008)

The Dual Energy Source Computed Tomography Imaging features two X-ray sources and two radiation detectors, which allow for faster imaging of patients and with less radiation. The new speed allows doctors to image patients with high or irregular heart rates, something that had been more difficult. Clinicians are applying this technology to vascular imaging, CT colonography and some types of cancer.

Said Dr. Michael Roizen, the chief wellness officer at Cleveland Clinic: "Now you can get a scan that used to take a couple of hours in the time it takes to get a cup of coffee."

9. Retinal Prosthesis (2014) Retinal prostheses have now been successfully implanted into over 130 patients around the world and are beginning to be tested for other patients who are blind due to a variety of diseases other than retinitis pigmentosa. Positive, long-term study results published in early 2015 affirm novel improvement in these patients' quality of life and independence.

10. Genome Guided Solid Tumor Diagnosis (2014)

With continuing research, genomic tests are now available for various types of cancer, including melanoma and cancers of the brain, lung, thyroid and pancreas. Multiple clinical trials are ongoing to evaluate the efficacy of integrating genomic-driven tumor testing, with databases compiling data to compare treatment options based on genomics rather than cancer type.

By 2016, this growing field of genome-guided tumor diagnostics has an expected market value of $26 billion.

About Cleveland Clinic

Cleveland Clinic is a nonprofit multispecialty academic medical center that integrates clinical and hospital care with research and education. Located in Cleveland, Ohio, it was founded in 1921 by four renowned physicians with a vision of providing outstanding patient care based upon the principles of cooperation, compassion and innovation. Cleveland Clinic has pioneered many medical breakthroughs, including coronary artery bypass surgery and the first face transplant in the United States. U.S.News & World Report consistently names Cleveland Clinic as one of the nation's best hospitals in its annual "America's Best Hospitals" survey. More than 3,000 full-time salaried physicians and researchers and 11,000 nurses represent 120 medical specialties and subspecialties. The Cleveland Clinic health system includes a main campus near downtown Cleveland, eight community hospitals, more than 90 northern Ohio outpatient locations, including 18 full-service family health centers, Cleveland Clinic Florida, the Lou Ruvo Center for Brain Health in Las Vegas, Cleveland Clinic Canada, and Cleveland Clinic Abu Dhabi. In 2014, there were 5.9 million outpatient visits throughout the Cleveland Clinic health system and 152,500 hospital admissions. Patients came for treatment from every state and 147 countries. Visit us at Follow us at

SOURCE Cleveland Clinic

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