Framingham, Mass., April 22, 2008 —- Netezza Corporation (NYSE Arca: NZ), the global leader in data warehouse and analytic appliances, today announced that Shire, a global specialty biopharmaceutical company, has chosen the Netezza Performance Server® (NPS®) appliance for its global enterprise data warehouse platform.

Shire has seen rapid growth over the last several years and in turn experienced soaring data volumes, so it needed a data warehouse and analytic solution that could handle these volumes cost-effectively. The company chose Netezza for its scalable, yet simple, approach to data warehousing and its ability to show tremendous performance.

“As data volumes continue to multiply exponentially – and the pharmaceutical industry is no exception – it’s essential for businesses to choose data warehouse technologies that will grow with them,” said Jim Baum, president and COO at Netezza. “Companies that value simplicity, scalability and high performance for their analytics continue to turn to Netezza’s data warehouse appliances as the best option to position them for future growth and success.”

The Netezza Performance Server family of data warehouse and analytic appliances is designed specifically for high-performance, terascale analytics, and architecturally integrates a relational database, server and storage into a single compact and power-efficient unit. The system’s advantage comes from its patented streaming architecture. Netezza has placed processing power next to the data, so analysis occurs at the source at streaming speeds, delivering an unprecedented 10-100 times the performance of traditional systems at a fraction of the cost. Analyses that took days now take just seconds. This means a dramatic increase in productivity across the enterprise and faster time to value for business initiatives. Netezza appliances are changing the way organizations leverage information, creating a powerful analytic foundation for a new generation of business analytics that improve strategic decision-making and drive results.

About Shire PLC

Shire’s strategic goal is to become the leading specialty biopharmaceutical company that focuses on meeting the needs of the specialist physician. Shire focuses its business on attention deficit and hyperactivity disorder (ADHD), human genetic therapies (HGT), gastrointestinal (GI) and renal diseases. The structure is sufficiently flexible to allow Shire to target new therapeutic areas to the extent opportunities arise through acquisitions. Shire believes that a carefully selected portfolio of products with a strategically aligned and relatively small-scale sales force will deliver strong results.

Shire’s focused strategy is to develop and market products for specialty physicians. Shire’s in-licensing, merger, and acquisition efforts are focused on products in niche markets with strong intellectual property protection either in the US or Europe.

For further information on Shire, please visit the Company’s Web site: www.shire.com.

About Netezza Corporation

Netezza is the global leader in data warehouse and analytic appliances that dramatically simplify high-performance analytics for business users across the extended enterprise, delivering significant competitive and operational advantage in today’s information-intensive marketplaces. The Netezza family of streaming analytic™ appliances brings appliance simplicity to a broad range of complex data warehouse and analytic challenges. Customers who have realized the benefits of Netezza appliances include Ahold, Amazon.com, CNET Networks, Debenhams, Department of Veterans Affairs, Epsilon, Nationwide, Neiman Marcus, Orange UK, Premier, Inc., Ross Stores, Ryder System, Inc., The Carphone Warehouse, The Sherwin-Williams Company and Virgin Media. Based in Framingham, Mass., Netezza has offices in Washington, DC, the United Kingdom and Asia Pacific. For more information about Netezza, please visit www.netezza.com.

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Netezza, Netezza Performance Server, NPS and streaming analytic are trademarks of Netezza Corporation. Other names may be trademarks of their respective owners.